巴西首次报告Moraxella oculi在传染性牛角膜炎疫情中
Clarissa Vidal de Carvalho1, Robert Domingues2,3, Cinthia de Carvalho Coutinho1
1Instituto de Ciência Biológicas, Universidade Federal de Juiz de Fora, 36036-900, Juiz de Fora, Brazil.
Veterinary research communications
|March 19, 2025
概括
这项研究首次在巴西确定了Moraxella oculi作为感染性牛角膜炎 (IBK) 的原因. 鉴定到的细菌显示出对抗生素的敏感性,为牛眼病管理提供了洞察力.
科学领域:
- 兽医微生物学 兽医微生物学
- 动物眼科 动物眼科
- 细菌基因组学 细菌基因组学
背景情况:
- 传染性牛角结膜炎 (IBK) 是全球普遍存在的牛眼病,由摩拉塞拉细菌引起.
- 症状从撕裂和疼痛到角膜不透明和潜在的失明.
- 准确识别致病的Moraxella物种对于有效的疾病管理至关重要.
研究的目的:
- 为了描述2022年巴西Minas Gerais的IBK爆发中涉及的Moraxella物种.
- 报告巴西首次隔离Moraxella oculi及其与其他菌株的遗传关系.
- 评估分离的细菌对抗生素的敏感性.
主要方法:
- 采集了来自18头症状呈现的霍尔斯坦牛的眼部抽样.
- 进行了细菌隔离,生理测试,PCR-RFLP和DNA测序.
- 进行了比较基因组分析,使用16-23SrRNA位置和平均核酸标识.
主要成果:
- 确定了Moraxella bovoculi基因型1和Moraxella oculi的五个分离物.
- 这是巴西首次报告Moraxella oculi,全球第二次报告.
- 没有检测到Moraxella bovis;所有分离物对测试的抗生素敏感.
- 基因组分析显示,巴西M. oculi和美国菌株之间存在很高的相似性 (99.5% 16-23S rRNA, 99.0% ANI).
结论:
- 在巴西IBK爆发中,Moraxella oculi被确定为一个重要的病原体.
- 这些发现扩大了对M. oculi分布的地理理解.
- 抗生素敏感性数据为该地区的IBK治疗策略提供了基础.
相关概念视频
Microbiome of the Eye
67
The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
67
Investigation of Disease Outbreaks
74
Multistate foodborne outbreaks pose significant public health risks and require meticulous investigation to identify sources and implement control measures. The Centers for Disease Control and Prevention (CDC) utilizes a dynamic seven-step process for these investigations, integrating data from laboratories, interviews, and environmental assessments to protect public health.Outbreak Detection: The detection of multistate outbreaks typically begins with PulseNet, the CDC's national laboratory...
74
Staphylococcal Skin Infections
143
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
143
Clinical Significance of Antibiotic Resistance
90
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
90
Bacterial Meningitis I: Introduction
15
Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
15
Bacterial Meningitis II: Pathophysiology
24
Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
24


