静脉注射菌素的现实世界使用,有效性和安全性:FORTRESS研究
Klaus-Friedrich Bodmann1, Stefan Hagel2, Alessandra Oliva3
1Kliniken Nordoberpfalz AG, Klinikum Weiden, Weiden, Germany.
Infectious diseases and therapy
|March 19, 2025
概括
静脉注射的菌素 (FOS) 有效地治疗严重的格拉姆阳性和格拉姆阴性感染,包括由多药耐药细菌引起的感染. 这项大型现实研究证实了其作为联合治疗伙伴的安全性和有效性.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 临床微生物学 临床微生物学
背景情况:
- 静脉注射菌素 (FOS) 是一种广泛的抗生素,用于严重感染.
- 它经常用于对抗格拉姆阳性 (GP) 和格拉姆阴性 (GN) 病原体的联合治疗,包括多药耐药 (MDR) 细菌.
研究的目的:
- 评估静脉注射FOS的实际有效性,安全性,使用模式和患者特征.
- 这项研究是迄今为止对FOS的最大评估.
主要方法:
- 一项前性,非干预性,多中心研究的中间分析.
- 2017年1月至2023年11月期间,从五个欧洲国家 (德国,意大利,英国,希腊,奥地利) 的716名患者收集的数据.
主要成果:
- 常见的适应症包括细菌病/败血症,复杂的尿路感染和骨/关节感染.
- 在Klebsiella spp.中,MDR病原体的流行率为34.6%,高抗卡巴胺耐药性 (48.0%). 感染. 感染.
- FOS表现出良好的临床成功 (75.3%) 和微生物治疗 (82.4%),包括在MDR/CR感染 (78.0%). 电解质失衡是最常见的药物不良反应.
结论:
- 静脉注射福米是一种安全有效的组合治疗药物,用于治疗严重的GP和GN感染.
- 它对深层感染和涉及MDR细菌的感染特别有价值.
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