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Updated: May 21, 2025

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在HR修复过程中,TAOK1通过酸化USP7促进了线材的形成

Tian-Chen Zhu1,2, Zhang-Ping He3, Shu-Ting Li1,2

  • 1State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou 510000, China.

Proceedings of the National Academy of Sciences of the United States of America
|March 19, 2025
PubMed
概括

一千和一个氨基酸蛋白激酶1 (TAOK1) 抑制增强了PARP抑制剂在癌症中的有效性. 阻断TAOK1或其与USP7的相互作用会降解RAD51,破坏DNA修复并增加癌细胞对PARP抑制剂的敏感性.

关键词:
这是一种PARP抑制剂.这就是TAOK1的意义.膀癌:膀癌是一种癌症.同类的重组组合.合成杀伤性 合成杀伤性

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