在严重的慢性鼻炎与鼻的成年人中使用Tezepelumab
Brian J Lipworth1, Joseph K Han2, Martin Desrosiers3
1Scottish Centre for Respiratory Research, and ENT Rhinology Clinic, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom.
The New England journal of medicine
|March 19, 2025
概括
采佩卢马布显著改善了鼻息肉症状,并减少了在患有鼻息肉的严重慢性鼻炎的成年人手术或全身类固醇的需要.
科学领域:
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 肺部病理学 肺部病理学
背景情况:
- 严重的,不受控制的喘与慢性鼻炎与鼻息肉 (CRSwNP) 显示了对tezepelumab对鼻症状的一些反应.
- 在严重,不受控制的CRSwNP的成年人中,tezepelumab的有效性和安全性仍然是未知的.
研究的目的:
- 评估tezepelumab在患有严重,不受控制的CRSwNP的成年人中的疗效和安全性.
主要方法:
- 一项随机的,安慰剂对照试验分配了患有严重CRSwNP的成年人接受tezepelumab (210 mg) 或安慰剂每4周进行一次皮下注射,持续52周.
- 共同初级终点包括52周总鼻息肉得分和平均鼻塞得分的变化.
- 二级终点包括嗅觉丧失,SNOT-22,Lund-Mackay和总症状得分,以及鼻息肉手术或全身糖皮质激素使用的时间到事件分析.
主要成果:
- 与安慰剂 (P<0.001) 相比,Tezepelumab治疗导致鼻多得分 (平均差异 -2.07) 和鼻塞 (-1.03) 的显著改善.
- 在tezepelumab的嗅觉丧失,SNOT-22,Lund-Mackay和总症状得分中观察到显著的改善 (所有人P<0.001).
- 鼻息肉手术的发生率从安慰剂组的22.1%下降到tezepelumab组的0.5%,全身葡萄糖皮质体的使用率从18.3%下降到5.2% (P<0.001两者).
结论:
- 在严重CRSwNP的成年人中,Tezepelumab治疗显著降低了鼻息肉大小,堵塞和整体鼻腔症状.
- 与安慰剂相比,tzepelumab 显著降低了需要进行鼻息肉手术和全身使用葡萄糖皮质激素的需要.
- 佩鲁马布在治疗严重,不受控制的CRSwNP时表现出显著的疗效和安全性.
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