Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Hematopoiesis01:21

Hematopoiesis

5.0K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
5.0K
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

3.6K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
3.6K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.0K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.0K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.1K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

tRNA m<sup>1</sup>A modification ensures HSPC production via modulating Nrf1 translation in zebrafish.

EMBO reports·2026
Same author

tRNA-m1A Modification Safeguards Fetal Liver HSPCs from DNA Damage via Maintaining Iron Homeostasis.

Blood·2026
Same author

Genetic recording of pancreatic beta cell proliferation.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

When imaging technology meets single-cell omics: new paradigm in developmental biology.

Cell regeneration (London, England)·2025
Same author

Ace2 safeguards embryonic hematopoietic stem and progenitor cell production by restraining Nlrp3-mediated pyroptosis.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

DNA methyltransferase Dnmt3ba-mediated epigenetic modulation of Integrin signaling is essential for hematopoietic stem and progenitor cell development.

Communications biology·2025
Same journal

Real-time Targeted Enrichment in Single-cell Long-read Sequencing.

Genomics, proteomics & bioinformatics·2026
Same journal

Decoding RNA N6-Methyladenosine Methylome of Wheat Using Machine Learning and Nanopore Direct RNA Sequencing.

Genomics, proteomics & bioinformatics·2026
Same journal

Tranquillyzer: A Neural Network Framework for Long-read Annotation and Demultiplexing.

Genomics, proteomics & bioinformatics·2026
Same journal

Advancing Functional Transcriptomics in Zebrafish with High-accuracy Full-length RNA Sequencing.

Genomics, proteomics & bioinformatics·2026
Same journal

NanoRAPID: A Deep Learning-based Framework for Single-molecule RNA Structure Analysis Using Nanopore Direct RNA Sequencing.

Genomics, proteomics & bioinformatics·2026
Same journal

Single-cell Multiomic and Spatiotemporal Dissection of the Liver Circadian Clock.

Genomics, proteomics & bioinformatics·2026
查看所有相关文章

相关实验视频

Updated: May 21, 2025

Author Spotlight: Advancing In Vitro Blood Cell Production with Single-Cell Multiomics and Functional Genomics
04:11

Author Spotlight: Advancing In Vitro Blood Cell Production with Single-Cell Multiomics and Functional Genomics

Published on: March 15, 2024

1000

血 Atlas:一个多组的血液形成数据库.

Zhixin Kang1,2,3, Tongtong Zhu4,5,3, Dong Zou4,5

  • 1State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

Genomics, proteomics & bioinformatics
|March 19, 2025
PubMed
概括
此摘要是机器生成的。

海马图谱绘制了跨物种和条件的血液形成图,有助于理解血液发育,并在体外产生血液形成的干细胞和祖先细胞 (HSPC).

关键词:
跨物种分析进行跨物种分析.发育性血液形成造血细胞的数据库 造血细胞的数据库血液构造干细胞和原始细胞在体外.多个omics的多个omics.

更多相关视频

Author Spotlight: Advancing Hematopoietic Research Using Stromal Cell Isolation for Single Cell Sequencing
05:27

Author Spotlight: Advancing Hematopoietic Research Using Stromal Cell Isolation for Single Cell Sequencing

Published on: January 26, 2024

992
Enumeration of Major Peripheral Blood Leukocyte Populations for Multicenter Clinical Trials Using a Whole Blood Phenotyping Assay
14:45

Enumeration of Major Peripheral Blood Leukocyte Populations for Multicenter Clinical Trials Using a Whole Blood Phenotyping Assay

Published on: September 16, 2012

14.9K

相关实验视频

Last Updated: May 21, 2025

Author Spotlight: Advancing In Vitro Blood Cell Production with Single-Cell Multiomics and Functional Genomics
04:11

Author Spotlight: Advancing In Vitro Blood Cell Production with Single-Cell Multiomics and Functional Genomics

Published on: March 15, 2024

1000
Author Spotlight: Advancing Hematopoietic Research Using Stromal Cell Isolation for Single Cell Sequencing
05:27

Author Spotlight: Advancing Hematopoietic Research Using Stromal Cell Isolation for Single Cell Sequencing

Published on: January 26, 2024

992
Enumeration of Major Peripheral Blood Leukocyte Populations for Multicenter Clinical Trials Using a Whole Blood Phenotyping Assay
14:45

Enumeration of Major Peripheral Blood Leukocyte Populations for Multicenter Clinical Trials Using a Whole Blood Phenotyping Assay

Published on: September 16, 2012

14.9K

科学领域:

  • 血液学 血液学 血液学
  • 系统生物学 系统生物学
  • 基因组学就是基因组学.

背景情况:

  • 高通量omics技术使得血液构造器官的系统探索成为可能.
  • 了解体内造血和体内造血干细胞和原生细胞 (HSPC) 产生需要跨物种的发育格局.

研究的目的:

  • 开发HemAtlas,这是一个系统地绘制体内和体外血液形成的平台.
  • 为探索跨物种和实验模型的多学科数据提供全面的资源.

主要方法:

  • 来自人类,小鼠,斑马鱼和体外HSPC培养的综合多omics数据集.
  • 使用文献策划,数据规范化和统一整合方法.
  • 开发了功能模块,用于交互式数据探索和可视化.

主要成果:

  • 构建了全器官的造血参考,并对每个物种进行了手动策划的细胞注释.
  • 启用跨阶段,跨物种和跨模型单细胞分析.
  • 通过全面的跨阶段开发地图,揭示了HSPC阶段特定的特性.

结论:

  • 血质图提供了一个至关重要的资源,以促进对血液形成的理解.
  • 该平台有助于在体外生成功能性HSPC.
  • 海马特拉斯能够在器官层面全面解码跨阶段发育性血液形成.