埃塞俄比亚狂犬病的发病率,风险因素和控制:系统审查和元分析
Belay Tafa Regassa1, Wagi Tosisa1, Daniel Eshetu2
1Department of Medical Laboratory Sciences, College of Health Sciences and Referral Hospital, Ambo University, Ambo, Ethiopia.
PLoS neglected tropical diseases
|March 19, 2025
概括
狂犬病在埃塞俄比亚构成重大风险,人类暴露在狂犬病动物和人类狂犬病死亡的高率. 一个健康的方法对于有效的狂犬病预防和控制至关重要.
科学领域:
- 兽医公共卫生 兽医公共卫生
- 流行病学 流行病学
- 传染性疾病 传染性疾病
背景情况:
- 狂犬病是一种全球性动物传播疾病,每年造成数万例死亡,主要发生在发展中国家.
- 埃塞俄比亚的狂犬病流行程度很高,但缺乏全面的风险评估.
研究的目的:
- 估计埃塞俄比亚被怀疑狂犬病动物的人类暴露的综合发病率.
- 确定该地区人类和家禽狂犬病发病率.
主要方法:
- 在PubMed,Scopus,Embase和Web of Science数据库中进行系统的文献搜索,直到2023年10月.
- 使用乔安娜·布里格研究所 (JBI) 检查清单进行质量评估,并遵守PRISMA 2020指南.
- 使用随机效应模型与综合元分析 (CMA) 软件进行定量合成;通过Q统计和I2评估异质性;使用埃格尔回归测试评估出版偏差.
主要成果:
- 人类接触疑似狂犬病动物的年度综合发病率为每10万人中33.65.
- 估计每年人类狂犬病死亡人数为每百万人口4.57人.
- 狗的发病率最高 (120.99/100,000),其次是马和牛;儿童受到暴露和死亡的影响不成比例.
结论:
- 在埃塞俄比亚观察到人类暴露于狂犬病动物的高综合发病率和人类和动物的狂犬病率显著.
- 通过一种健康方法加强跨部门和跨学科的合作对于预防和控制狂犬病至关重要.
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