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Updated: May 21, 2025

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AGO2通过抑制瘤IFN-马反应依赖的CD8+ T细胞免疫力来调解免疫疗法失败

Yuzhao Wang1, Zibin Chen1, Ke Liang1

  • 1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China; Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.

Cell reports
|March 19, 2025
PubMed
概括

阿尔戈纳特2 (AGO2) 通过抑制干扰素- (IFN-γ) 信号,阻碍癌症免疫疗法. 在临床前模型中,抑制AGO2或miR-1246可以恢复免疫反应,并提高治疗疗效.

关键词:
一个AGO2的AGO2在CD8 T细胞中,CD8 T细胞CP: 癌症 癌症 癌症CP: 免疫学 免疫学美国国家统计局 (STAT1)抗瘤免疫力 免疫力膀癌:膀癌是一种癌症.免疫疗法 免疫疗法干扰因子的马反应反应微型RNA是指一个微型RNA.瘤免疫的微环境

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