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Updated: May 21, 2025

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基于PAMAM的DNA光纳米探针用于快速全细胞APE1检测和成像

Huimin Li1, Xinru Yuan1, Mei Ren1

  • 1State Key Laboratory of Organic-Inorganic Composites, Beijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.

Analytical chemistry
|March 19, 2025
PubMed
概括

一个新的光纳米探针快速检测细胞中的阿普里尼克/阿普里米尼克内核酶1 (APE1),用于早期癌症诊断. 这种先进的工具增强了核APE1可视化,并大大加快了检测时间.

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相关概念视频

Protein Dynamics in Living Cells01:19

Protein Dynamics in Living Cells

Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...
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