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Updated: May 21, 2025

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
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Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding

Published on: June 9, 2017

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结构和动力学决定了A类GPCR的G蛋白合特异性.

Marina Casiraghi1, Haoqing Wang1, Patrick C Brennan2

  • 1Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.

Science advances
|March 19, 2025
PubMed
概括

这项研究揭示了G蛋白结合受体 (GPCR) 如何通过改变它们的结构来结合不同的G蛋白来实现特定的信号传递. 开发一个有偏见的激动剂为GPCR-G蛋白相互作用提供了新的见解.

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