微流体衍生蒙莫里隆尼特复合微粒用于口服共递益生菌生物膜和后生菌
Zhonglin Fang1, Xinyuan Yang1, Luoran Shang1
1Shanghai Xuhui Central Hospital, Zhongshan-Xuhui Hospital, and the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.
Science advances
|March 19, 2025
概括
这项研究开发了先进的微粒,用于口服提供益生菌和后生菌来治疗性结肠炎 (UC). 这种新型配方改善了肠道保留,并在小鼠模型中有效降低了炎症.
科学领域:
- 胃肠道学和微生物学
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
背景情况:
- 口服益生菌显示出性结肠炎 (UC) 的潜力,但面临着退化和粘附性差等挑战.
- 目前对UC的治疗方法受到疗效和副作用的限制.
- 开发有效的输送系统对于增强益生菌治疗至关重要.
研究的目的:
- 创建耐酸,肠道响应的复合微粒,用于共传递益生菌Lactobacillus acidophilus (LA) 生物膜和后生物.
- 提高UC治疗口服益生菌的稳定性,粘膜粘附性和治疗疗效.
- 研究这些微粒在缓解大肠炎方面的潜力.
主要方法:
- 利用微流体电子喷雾制造复合微粒,封装蒙特莫里隆尼特支持的LA生物膜和英多尔-3-酸.
- 评估了微粒子的抗酸性和肠道环境的响应性.
- 在大肠炎的小鼠模型中评估治疗效果,测量炎症标志物,肠道屏障功能和肠道微生物群组成.
主要成果:
- 开发出稳定,耐酸的微粒,改善了LA生物膜的肠道保留.
- 在小鼠中显著缓解大肠炎,包括减少炎症和改善肠道屏障功能.
- 显示了复合微粒物后肠道微生物群组成的调节.
结论:
- 复合微粒为增强益生菌和后生菌的口服输送提供了一个有希望的策略.
- 这种新的配方在临床前模型中有效地减轻结肠炎.
- 开发的微粒系统具有提高UC治疗中的益生菌疗效的巨大潜力.
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