在爱尔兰2022-2023年爆发期间,儿童侵袭性A组链球菌感染的流行病学变化
Deirdre J Foley1, Orla Cotter2, Lucy Davidson1
1From the Paediatric Infectious Diseases Department, Children's Health Ireland, Dublin, Ireland.
The Pediatric infectious disease journal
|March 19, 2025
概括
在爱尔兰,儿童的侵袭性A组链球菌 (iGAS) 激增. 病毒共感染和快速恶化强调了对败血症的认识和更广泛的疫苗接种的需要,包括麻疹疫苗.
科学领域:
- 儿童传染病 儿童传染病
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 在爱尔兰,从2022年10月到2023年6月,儿科侵袭性A型 estreptococcus (iGAS) 病例显著增加了4倍.
- 这种增加促使人们对儿童iGAS的临床特征和疾病进展进行了调查.
研究的目的:
- 在发病率增加的时期分析儿科iGAS病例的临床特征和结果.
- 为公共卫生战略,临床指导和公众宣传活动提供信息.
主要方法:
- 对所有在16岁以下儿童中报告的IGAS病例的回顾性审查 (2022年10月 - 2023年6月).
- 用在线问卷对住院和死亡进行临床病例审查.
- 统计分析包括费舍尔的精确测试和差异分析.
主要成果:
- 在180例iGAS病例中,有167例具有临床数据. 33/49人患有皮肤感染同时患有水; 69/167人患有呼吸道病毒共感染.
- 74/167需要程序性干预,而34/167需要小儿重症监护室的入院.
- 在12例死亡中,10例患有死性肺炎,8例患有医院外心脏骤停. 流行病学转向呼吸道诊断,增加了对干预的需求.
结论:
- 儿科iGAS病例的快速,严重恶化和死亡率强调了医疗机构对败血症意识的急需.
- 病毒共同感染的高率凸显了现有的疫苗接种计划的重要性,并将其扩展到包括疹病毒.
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