在丹麦和英格兰,对脆弱的癌症患者进行临床试验参与
Lars Hernández Nielsen1, Jakob Bruhn Krøjgaard Skelmose2, Laurids Østergaard Poulsen3
1Center for Clinical Data Science, Department of Clinical Medicine, Aalborg University, and Research, Education and Innovation, Aalborg University Hospital, Denmark; Danish Center for Health Services Research, Department of Clinical Medicine, Aalborg University, Denmark.
Cancer epidemiology
|March 19, 2025
概括
丹麦和英格兰的脆弱癌症患者在临床试验中的参与减少,特别是对于妇科癌症. 这突出了访问障碍,并影响了试验的通用性.
科学领域:
- 在瘤学瘤学.
- 临床试验 临床试验
- 医疗保健服务研究 医疗服务研究
背景情况:
- 临床试验对于推进癌症疗法至关重要.
- 符合条件的标准可能会限制弱势患者群体的访问.
- 了解参与差异是提高试验概括性的关键.
研究的目的:
- 调查丹麦脆弱癌症患者参与临床试验的情况.
- 为了比较丹麦和英格兰脆弱和非脆弱患者之间的试验参与率.
主要方法:
- 分析了丹麦 (2008-2021) 和英格兰 (2016-2019) 系统性抗癌疗法的基于人口的注册表.
- 包括接受全身抗癌治疗的患有固体癌症的成年患者.
- 脆弱性是根据社会经济地位 (最低五分之一) 定义的;估计了参与试验的几率比率.
主要成果:
- 包括丹麦的15173名患者和英格兰的336218名患者.
- 易受伤害的患者参与试验的几率较低:调整后OR在丹麦为0.81,在英国为0.80.
- 弱势群体参与率降低在妇科癌症中最为明显.
结论:
- 在丹麦和英国,脆弱的癌症患者在临床试验中的参与率较低.
- 在妇科癌症中观察到减少参与的一致关联.
- 调查结果强调,需要解决弱势群体进入临床试验的障碍.
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