生物仿真刺激模式驱动自然的人工触觉感知使用人体内皮层微刺激
Taylor G Hobbs1,2,3, Charles M Greenspon4, Ceci Verbaarschot2,5
1Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States of America.
Journal of neural engineering
|March 19, 2025
概括
模仿自然神经活动的生物仿真刺激模式显著增强了通过皮层内微刺激 (ICMS) 引起的人工触觉感觉的感知自然性. 这种方法还需要较少的电荷来进行强度匹配的感知,从而改善脊髓损伤患者的触觉反.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 康复医学 康复医学 康复医学
背景情况:
- 人体体感官皮层中的皮层内微刺激 (ICMS) 可以唤起触觉感知,但这些人造感觉往往缺乏自然性.
- 优化ICMS参数以增加唤起的感觉的自然性对于开发有效的神经假肢和感官反系统至关重要.
研究的目的:
- 研究生物模拟刺激模式是否复制自然神经活动特征,与非生物模拟模式相比,增强ICMS唤起的触觉感觉的感知自然性.
- 评估简单 (单电极振幅调制) 和高级 (多电极时空动力学) 仿生ICMS方案的有效性.
主要方法:
- 三名椎脊髓损伤和植入体感皮质电极阵列的人参与了这项研究.
- 参与者将ICMS引起的感知与他们手上的机械痕引起的自然触觉感知进行了比较.
- 生物仿真和非生物仿真ICMS模式被系统地评估,以感知自然性和充电效率.
主要成果:
- 对于32%的电极来说,简单的生物模拟ICMS策略 (单电极振幅调制) 被认为比非生物模拟模式更自然.
- 一个先进的仿生方案,捕捉四个电极的时空动态,被认为是75%的电极组更自然.
- 与非仿生模式相比,生物模拟刺激列车需要更少的电荷来达到强度匹配的感觉.
结论:
- 模仿自然体感官皮层空间时空激活模式的ICMS编码方案导致更自然的感觉的人工触觉感觉.
- 生物仿真方法为改善神经假体中的感官反提供了一个有希望的策略,并可能指导未来的刺激参数优化.
- 这项研究表明,结合自然神经活动的原则可以提高ICMS在感官恢复方面的有效性和效率.
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