成年女性的细颗粒物成分和生殖激素:15年纵向队列研究
Siyi Chen1, Cui Guo2, Chunquan Ou3
1Department of Urban Planning and Design, Faculty of Architecture, The University of Hong Kong, Hong Kong, China.
International journal of hygiene and environmental health
|March 19, 2025
概括
长期暴露于细颗粒物 (PM2.5) 和其成分,特别是黑碳,显著影响女性生殖荷尔蒙,如FSH和LH. 空气污染控制可以有利于妇女的生殖健康.
科学领域:
- 环境健康 环境健康
- 生殖内分泌学 生殖内分泌学
- 毒理学 毒理学 毒理学
背景情况:
- 关于环境细颗粒物 (PM2.5) 和其成分对成年女性生殖激素水平的长期影响的研究有限.
- 了解这些影响对于公共卫生计划和生殖健康至关重要.
研究的目的:
- 调查长期暴露于PM2.5及其成分与女性成年人群的生殖激素水平之间的关联.
- 确定最显著影响荷尔蒙平衡的特定PM2.5成分.
- 探索不同的人口群体之间易感性的潜在差异.
主要方法:
- 在台湾进行了一项为期15年的回顾性队列研究 (2003-2017年),涉及17,152名女性成年人.
- 评估PM2.5及其组成部分 (硫酸盐,酸盐,,有机物,黑碳) 的两年平均度.
- 线性混合模型被用来分析与卵泡刺激激素 (FSH),黄素化激素 (LH), (T),雌激素 (E2) 和益生菌素 (PRL) 的关联.
主要成果:
- 增加的PM2.5暴露与更高的FSH和LH水平有关,黑碳显示最强的关联.
- 此外,PM2.5成分与雌性醇的降低和益生菌素水平的增加有关.
- 在年轻成年人中观察到与丸激素水平的积极关联,更年期后的女性对PM2.5影响的敏感性更大.
结论:
- 长期暴露于PM2.5及其成分对女性的荷尔蒙平衡有不利影响,阐明了空气污染对生殖健康影响的生物机制.
- 建议实施更严格的空气污染控制措施,以保护成年女性的生殖健康,即使是在污染水平中等的地区.
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