在儿童中发生的因性脱髓化病变
Ayberk Selek1, Rahsan Göcmen2, Ceren Günbey1
1Hacettepe University, Departmant of Child Neurology, Turkey.
概括
儿童的形性脱髓化病变 (TDL) 经常出现运动症状,难以诊断. 多重的TDL和积极的寡头克隆带表明多发性硬化症 (MS),需要持续的放射性监测来确定确诊.
科学领域:
- 儿科神经学 儿科神经学
- 神经成像是一种神经成像.
- 脱线性疾病 脱线性疾病
背景情况:
- 原性脱髓化病变 (TDL) 是MRI上的大型 (大于2厘米) 脑病变.
- 它们的尺寸和成像特征可以模仿其他病理,使诊断复杂化.
研究的目的:
- 调查儿童TDL的临床和放射性特征.
- 分析随访数据并确定TDL的儿科患者的最终诊断.
主要方法:
- 对儿童患者 (18岁以下) 的医疗记录 (1992-2017年) 的回顾性审查,在初始MRI上有TDL.
- 对临床表现,放射学发现和成像演变的分析.
主要成果:
- 大多数儿科患者呈现出急性多症状神经系统缺陷,主要是运动.
- 多发性硬化症 (MS) 是最常见的诊断 (66.6%),90%在随访期间被诊断出来.
- TDLs经常与其他脱髓化病变 (80%) 相伴发生,主要是表面的,并且通常会随着时间的推移而消失或缩小.
结论:
- 多个TDLs的存在,伴随着小的脱髓化病变,以及正脑脊液 (CSF) 基克隆带的存在可能表明儿童患有MS.
- 持续的放射性监测对于确定MS诊断至关重要,即使没有临床复发.
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