关于关疾病的遗传多态性:网络元分析
Daniel Augusto de Faria Almeida1, Camila Freire Brant2, Letícia da Costa Siqueira3
1School of Dentistry, Alfenas Federal University (Unifal-MG), Alfenas, Minas Gerais, Brazil; Department of Operative Dentistry and Dental Materials, School of Dentistry, Federal University of Uberlândia - UFU, Uberlândia, Minas Gerais, Brazil.
Archives of oral biology
|March 19, 2025
概括
神经传递,炎症和性激素基因中的遗传多态性是临时关疾病 (TMD) 的危险因素. COMT_rs165774 多态性显示出对肌痛和关节痛的保护作用.
科学领域:
- 遗传学 遗传学 是一个
- 口腔和牙面部外科手术
- 分子生物学分子生物学
背景情况:
- 关节疾病 (TMDs) 涵盖了一组影响关节 (TMJ) 和肌的疾病.
- TMDs的病因是多因素的,涉及遗传,环境和心理社会因素.
- 了解对TMDs的遗传倾向对于开发有针对性的预防和治疗策略至关重要.
研究的目的:
- 系统地审查和执行一个网络元分析 (NMA),比较各种遗传多形态对TMD易感性的影响.
- 根据其与不同TMD亚型的关联来对已识别的遗传多态进行排名.
主要方法:
- 在PROSPERO注册 (CRD42024507886) 后进行了系统审查和NMA.
- 在五个数据库中进行了电子搜索,搜索到2024年11月发布的相关研究.
- 系统性审查包括了63项研究,7项研究对NMA做出了贡献.
主要成果:
- 定性分析确定了120个与TMD相关的基因和206个多态.
- 24个基因中的32个多态系与整体TMD有关,22个基因中的22个多态系与退行性TMJ变化有关.
- 该COMT_rs165774多态体表现出对肌痛 (OR:0.33;95%CI:0.14-0.76) 和关节痛 (93%的概率) 的保护作用,在与神经传递,炎症,性激素,氧化应激和骨代谢相关的基因中发现了其他多态体.
结论:
- 调节神经传递,炎症反应和性激素的基因中的遗传多态性似乎是TMD病变的重要风险因素.
- 特定的多形态,如COMT_rs165774,可能会对某些TMD症状 (如肌痛和关节痛) 产生保护作用.
- 对TMDs遗传基础的进一步研究可以为个性化医疗方法提供信息.
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