在怀孕期间输血补充铁,剂量和时间:对母体输血减少捆绑的单一机构审查
Alixandria F Pfeiffer1, Nathalie Chang2, Oxana Zarudskaya1
1Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Texas Health San Antonio, San Antonio, TX, United States.
概括
在怀孕的第三个月初,静脉输入铁 (IVFe) 补充剂,特别是在更高剂量 (≥800 mg) 和至少在分娩前6周,显著改善了母亲的血红蛋白 (Hb) 水平.
科学领域:
- 产科和妇科 产科和妇科
- 血液学 血液学 血液学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 我们对静脉注射铁 (IVFe) 的时间和剂量如何影响母亲血红蛋白 (Hb) 的理解有限.
- 缺铁性贫血 (IDA) 在怀孕期间很常见,需要有效的治疗策略.
研究的目的:
- 为了确定IVFe的时间和剂量与产前Hb水平之间的关联.
- 评估IVFe对IDA孕妇Hb的影响.
主要方法:
- 对295名IDA孕妇接受铁糖糖 (Venofer®) 的回顾性队列研究.
- 分析IVFe时间 (输注时的妊娠年龄) 和剂量.
- 统计方法包括t测试,曼·惠特尼U,χ2测试,ANOVA和图基后期测试.
主要成果:
- 在怀孕34周之前给出的IVFe显示了较大的平均Hb增加 (2.5g/dL) 与后期给药 (1.3g/dL) 相比.
- 更高的IVFe剂量与分娩前增加的Hb和更长的输液到分娩间隔相关.
- 在剂量>800 mg和≥6-8周潜伏期时观察到的最佳Hb改善 (2.6-3.1 g/dL).
结论:
- 第三季度早期IVFe的使用,特别是用剂量≥800毫克和≥6周的潜伏期,为母亲的Hb.提供了实质性的好处.
- 优化IVFe时间和剂量可以提高IDA孕妇的治疗疗效.
相关概念视频
The Periodic Table and Organismal Elements
OverviewElements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally-occurring, and fewer still are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.The Periodic Table Provides Information...
Blood Transfusion and Agglutination
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Blood Transfusion
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Development of Blood Vessels
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
Fetal Circulation
Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...


