用ofatumumab治疗的复发性多发性硬化症患者对流感疫苗的免疫反应:来自开放标签,多中心,第四阶段研究的结果
Brian Steingo1, Adnan Subei2, Emily Riser3
1First Choice Neurology, 9970 N Central Park Blvd #207, Boca Raton, FL 33428, USA.
Multiple sclerosis and related disorders
|March 19, 2025
概括
接受ofatumumab (OMB) 的复发性多发性硬化症 (RMS) 患者对流感疫苗有不同的免疫反应. 在OMB启动前的疫苗接种通常会比OMB启动后的疫苗接种产生更好的免疫反应.
科学领域:
- 免疫学 免疫学 免疫学
- 神经学 神经学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 在复发性多发性硬化症 (RMS) 患者中,评估ofatumumab (OMB) 对流感疫苗免疫性的影响至关重要.
- 关于接受OMB治疗的RMS患者对疫苗的幽默免疫反应的数据有限.
研究的目的:
- 评估RMS患者在接受Ofatumumab (OMB) 治疗时对非活化流感疫苗的幽默免疫反应.
- 根据流感疫苗接种时间相对于OMB启动的时间来比较免疫反应.
主要方法:
- 一项涉及63名RMS患者 (18-55岁) 的研究,根据相对于OMB或其他疾病修饰疗法的流感疫苗接种时间分为三个队列.
- 血凝抑制 (HI) 标位在接种疫苗前和接种疫苗后4周测量,以评估血清保护和血清转化.
- 主要终点是疫苗接种后4周对流感菌株的血清保护 (HI标位≥40).
主要成果:
- 一些流感菌株的血清保护率通常很高,但在所有队列中的其他人中较低.
- 血清转换率因菌株而异,在OMB启动后接种疫苗的队列中趋势较低.
- 在OMB启动前接种疫苗的队列中,不良事件 (AE) 报告更频繁,可能是由于OMB启动本身.
结论:
- 一些接受ofatumumab治疗的RMS患者可能会对失活的流感疫苗产生免疫反应.
- 在开始使用ofatumumab之前的疫苗接种通常会导致较为有利的免疫反应,而不是在开始后的疫苗接种.
- 需要进一步的研究,因为T细胞的反应在本研究中没有被评估.
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