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红细胞密度对聚合能力作为细胞年龄标记物的影响:扩展性流动中的解离动态

Midhun Puthumana Melepattu¹, Guillaume Maîtrejean¹, Christian Wagner²

¹Université Grenoble Alpes, CNRS, Grenoble INP, LRP, Grenoble, 38000, France.

Journal of biomechanics

|March 19, 2025

概括

红细胞 (RBC) 聚合对于血液流动至关重要,随着细胞衰老变得更加强大. 密度较高的红细胞形成更强的聚合物,影响微循环和血液动力学.

科学领域:

生物物理学的生物物理.
血液学血液学血液学
微流体学微流体学

背景情况:

红血细胞 (RBC) 聚合显著影响血液风湿学和微循环.
红细胞聚合能力受到细胞衰老的影响,改变了机械和膜性质.

研究的目的:

调查不同细胞密度的红细胞聚合能力,这是红细胞衰老的标志物.
分析细胞密度对红细胞总体稳定性和解离率的影响.

主要方法:

使用Percoll密度梯度离心法将健康的供体红细胞分成密度分数.
利用微流体延伸流技术与过度压缩来研究聚合物解离.
采用卷积神经网络 (CNN) 进行红细胞聚合物的图像分析.

主要成果:

红细胞总分离率与细胞密度有很强的相关性.
从更密集的红细胞分数形成的聚合物与平均细胞群相比,表现出明显更大的强度.
微流体方法揭示了在与微循环相关的动态流量条件下的红细胞聚合物的行为.

结论:

红细胞老化在体内增强了由于改变的机械性质,聚合物的强度.
细胞衰老和红细胞衰老是影响血液动力学的关键因素.
开发的微流体技术为评估各种健康状况下红细胞聚合能力的现有方法提供了有价值的补充.

关键词:

红细胞细胞的聚合.细胞动态细胞动态红细胞衰老红细胞衰老扩展性流量是指扩展性流量.微血管流是指微血管流.

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