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Updated: May 21, 2025

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
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在多发性硬化症中,T-bet+ CXCR3+ B 细胞驱动高反应性 B-T 细胞相互作用

Ivan Jelcic1, Reza Naghavian2, Imran Fanaswala3

  • 1Neuroimmunology and MS Research Section (NIMS), Neurology Clinic, University of Zurich, University Hospital Zurich, 8091 Zurich, Switzerland; Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland.

Cell reports. Medicine
|March 19, 2025
PubMed
概括

研究人员发现T-bet+CXCR3+B细胞通过放大T细胞反应来驱动多发性硬化症 (MS) 的炎症. 这些细胞在大脑和外周系统中都至关重要,影响着MS的进展.

关键词:
用B-T细胞丰富的集群.在BTECBTECBTECBTECBTECBTECBTECBTECBTECCXCR3CXCR3CXCR3CXCR3CXCR3CXCR3CXCR3C在IFN-gamma的基础上.在T细胞,T细胞.在T-bet+B细胞中.自行扩散的自我扩散.自动反应性自动反应性.超反应性B-T细胞相互作用脑膜是指脑膜.多发性硬化症多发性硬化症自我的自我.

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