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免疫特征的树突与口腔状细胞癌中新辅助免疫疗法的反应有关

Yu-Tong Liu¹, Hai-Ming Liu¹, Jian-Gang Ren²

¹State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, China.

Cell reports. Medicine

|March 19, 2025

概括

免疫化学疗法增加了有益的瘤 stromal 细胞 (TSC) 和口腔癌响应者的特定血管. 这些变化创造了有利的微环境,与那些仅仅对免疫疗法的不响应者所见的不同.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
癌症生物学癌症生物学

背景情况:

瘤 stromal 细胞 (TSC) 是瘤微环境 (TME) 的关键组成部分,但仍未得到充分研究.
了解TSC的作用对于开发有效的癌症疗法至关重要.

研究的目的:

为了研究TSCs在口腔状细胞癌 (OSCC) 在不同的新辅助治疗后的作用.
识别与治疗反应和耐药性相关的特定 stromal 细胞种群.

主要方法:

在22名OSCC患者的瘤样本上进行了单细胞测序和空间转录学.
患者接受了抗PD-1单抗免疫疗法或抗PD-1加多塞塔克塞尔-西斯普拉丁-5-甲 (TPF) 免疫化学疗法.
分析的重点是与治疗反应相关的TSC和内皮细胞的变化.

主要成果:

免疫化疗反应者显示TSCs,SELP+高内皮静脉 (HEVs) 和APOD+肌纤维细胞癌相关纤维细胞 (myCAFs) 的增加.
在免疫化疗队列中观察到STMN1+毛细体内皮细胞 (cECs) 的减少.
对单一免疫疗法的不响应者表现出MYF5+肌肉卫星细胞 (MSC) 的上调.
SELP+ HEVs和APOD+ myCAFs形成了免疫调节,而STMN1+ cECs和MYF5+ MSCs形成了免疫抑制.

结论:

包括SELP+ HEVs和APOD+ myCAFs在内的特定树皮细胞种群与OSCC患者接受免疫化疗的良好结果有关.
STMN1+ cECs和MYF5+ MSCs有助于免疫抑制,并可能代表治疗点.
这些发现凸显了向树叶组件的潜力,以增强抗癌免疫力.

关键词:

免疫化学疗法免疫化学疗法新辅助免疫疗法新辅助免疫疗法一个单细胞分析.空间转录学空间转录学树皮细胞是干细胞的组成部分.

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