循环生物在阻塞性睡眠呼吸暂停与心血管疾病相关的循环生物
Laetitia S Gaspar1, Santoshi Pyakurel2, Na Xu3
1Centre for Neuroscience and Cell Biology, University of Coimbra, Portugal; Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Portugal.
Journal of molecular and cellular cardiology
|March 19, 2025
概括
循环节律障碍与阻断性睡眠呼吸暂停 (OSA) 和心血管疾病 (CVD) 有关. 这篇评论探讨了时钟失调如何可能连接OSA和CVD,影响心脏功能.
科学领域:
- 时间生物学 时间生物学
- 心脏病学 心脏病学
- 睡眠医学 睡眠医学
背景情况:
- 不调节的昼夜系统与阻塞性睡眠呼吸暂停 (OSA) 和心血管疾病 (CVD) 独立相关.
- 睡眠障碍和心血管疾病的共存是常见的,特别是在未经治疗的睡眠障碍患者中,但昼夜干扰的作用仍然不清楚.
- 昼夜节律影响许多生理功能,包括血压和心率,这表明存在潜在的机械联系.
研究的目的:
- 提供关于OSA中昼夜调节失调及其与心血管疾病相关性的全面概述.
- 探索连接OSA和CVD的潜在时钟调节机制.
- 讨论动物模型和未来的研究方向,以了解这种关系.
主要方法:
- 文献综述和综合现有关于昼夜节律,OSA和CVD的研究.
- 在OSA的背景下,识别潜在的分子和生理途径,将昼夜调节失调与心血管健康联系起来.
- 讨论实验研究的相关动物模型.
主要成果:
- 循环节失调是可能调解OSA和心血管疾病之间的关系的一个重要因素.
- 涉及多种时钟调节机制,包括氧气感应,炎症,心血管过程,氧化应激,代谢调节,激素信号和表观遗传学.
- 这篇评论强调了昼夜生物学,睡眠呼吸暂停和心脏病之间的相互作用的复杂性.
结论:
- 循环节失调是一种合理的机制,有助于OSA和心血管疾病的频繁共存.
- 需要进一步的研究,包括对动物模型的研究,以阐明这些复杂的关系.
- 了解这些联系可能会为患有OSA和心血管疾病的患者提供新的治疗策略.
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