小密度低密度脂蛋白作为老年人的生物标志物
Taina T Katajamäki1, Marja-Kaisa Koivula2, Marika J Salminen3
1Faculty of Medicine, Department of Clinical Medicine, Unit of Clinical Chemistry, University of Turku 20521 Turku, Finland; Wellbeing Services County of Southwest Finland, Turku University Hospital, Laboratory Division, 20521 Turku, Finland.
Clinical biochemistry
|March 19, 2025
概括
小密度低密度脂蛋白胆固醇 (sdLDL-c) 是64-76岁的老年男性新动脉样硬化心血管疾病 (ASCVD) 的重要预测因素. 这项研究发现,sdLDL-c在这个人口群体中,对于ASCVD风险的标志物比LDL-c更好.
科学领域:
- 心脏病学 心脏病学
- 脂质学 脂质学是指脂质学.
- 老年病的医生 老年病的医生
背景情况:
- 小密度低密度脂蛋白 (sdLDL) 是一种与动脉样硬化心血管疾病 (ASCVD) 相关的已知动脉质颗粒.
- 了解老年人中sdLDL胆固醇 (sdLDL-c) 的预测价值对于评估心血管风险至关重要.
研究的目的:
- 为了前性地评估sdLDL-c作为18年来64岁及以上个体新ASCVD的预测因素.
- 为了比较sdLDL-c与常规脂质和阿波利波蛋白在预测老年人ASCVD中的关联.
主要方法:
- 一项针对1770名年龄≥64岁的受试者进行的前性研究,随访时间为18年.
- sdLDL-c通过同质的,选择性的酶法测量.
- 传统的脂质 (TC,HDL-c,TG) 和阿波利波蛋白 (ApoA1,ApoB) 分别使用酶和免疫细胞计方法进行分析. 用弗里德沃尔德公式计算的LDL-c.
主要成果:
- sdLDL-c与LDL-c,非HDL-c,TC和ApoB正相关.
- 在随访期间,sdLDL-c在64-76岁的男性中与新的ASCVD有显著的关联 (调整HR: 1.61).
- 在研究的任何年龄组的老年男性 (77-97岁) 或女性中都没有发现显著的关联.
结论:
- 与目标相比,老年人脂质和非脂质蛋白水平通常较高.
- 基线脂质/脂蛋白水平在ASCVD和对照组之间没有差异.
- sdLDL-c与ApoB和LDL-c相比,对ASCVD的预测价值相当或更高,特别是在年轻的老年男性中.
相关概念视频
Blood Studies for Cardiovascular System III: Serum Lipid Profile
111
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
111
Cholesterol: Significance and Regulation
483
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
483
Inflammation
52.1K
Overview
52.1K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
40
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
40
Lipid-derived Compounds in the Human Body
4.3K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
4.3K


