相关实验视频

Updated: May 21, 2025

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

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3'未翻译区域的体质变体连接了人类癌症中的替代多基化失调

Qiushi Xu1, Xiaomeng Cheng2, Qianru Li2

  • 1State Key Laboratory of Genetic Engineering, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Collaborative Innovation Center of Genetics and Development, Human Phenome Institute, Center for Evolutionary Biology, Shanghai Engineering Research Center of Industrial Microorganisms, School of Life Sciences, Fudan University, Shanghai 200438, China; Center for Reproductive Medicine, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.

Journal of genetics and genomics = Yi chuan xue bao
|March 19, 2025
PubMed
概括

癌症3'未翻译区域 (3' UTRs) 的体质变体可以破坏信使RNA替代多基 (APA). 这项研究确定了与异常APA相关的众多变异,揭示了癌症中基因调节的新层.

关键词:
3′ UTR 的时间.替代性的多基解.癌症 癌症 癌症 癌症基因表达调节 基因表达调节身体变体的体质变体

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