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放射治疗耐药机制与瘤微环境之间的相互作用

Dengxiong Li¹, Jie Wang¹, Xinrui Li²

¹Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.

Critical reviews in oncology/hematology

|March 19, 2025

概括

癌症中放射治疗耐药性是一个主要的挑战,受瘤微环境 (TME) 的影响. 了解TME机制并针对它们,为改善癌症治疗结果提供了有希望的策略.

科学领域:

在瘤学瘤学.
癌症生物学癌症生物学
免疫治疗是一种免疫疗法.

背景情况:

放射治疗 (RT) 耐药性是癌症管理中的一个重要的临床障碍.
瘤微环境 (TME) 在调解对RT的耐药性方面发挥着关键作用.
了解TME驱动的RT耐药机制对于开发有效疗法至关重要.

研究的目的:

审查和讨论来自TME的RT电阻机制.
确定针对TME的治疗策略,以克服RT抵抗.
为突出探索RT耐药性的新兴技术.

主要方法:

使用PubMed和Web of Science数据库进行了叙事审查.
确定了研究,重点是从TME视角对RT耐药性的调节网络和治疗方法.
分析了关键的基因,通路和TME调节因子.

主要成果:

RT改变免疫TME,影响免疫细胞透和功能,这是RT抵抗的核心.
像自,衰老,氧化应激和血管生成这样的表型有助于RT抵抗.
确定了关键途径 (例如TGF-β,P53,NF-κB,cGAS/STING,ERK,AKT,STAT) 和TME向策略 (例如纤维细胞激活蛋白抑制剂,外体,纳米药物,免疫疗法).

结论:

复杂的RT-TME相互作用显著影响RT疗效.
新的TME准方法显示出克服RT阻力的希望.
需要利用人工智能和生物工程等先进方法进行进一步的研究,以改进治疗策略.

关键词:

免疫治疗是一种免疫疗法.辐射疗法辐射疗法抗辐射疗法耐药性抗辐射治疗耐药性衰老是一种衰老.瘤微环境是一个微环境.

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