后眼曲作为区分病理近视与高近视的生物标志物
Haichao Chen1, Zhe Pan1, Xinyu Liu2
1From the Beijing Visual Science and Translational Eye Research Institute (BERI) (H.C., Z.P., J.B.J., T.Y.W., Y.X.W.), Eye Center of Beijing Tsinghua Changgung Hospital, Tsinghua Medicine, Tsinghua University, Beijing, China.
American journal of ophthalmology
|March 19, 2025
概括
后眼曲度测量显示,在区分病态近视 (PM) 和简单高近视 (SHM) 方面有希望. 这些新的指标,特别是曲率max,在诊断中优于传统的轴长和折射误差.
科学领域:
- 眼科医生 眼科 眼科
- 生物医学工程 生物医学工程
- 医疗成像医学成像
背景情况:
- 近视,特别是病态近视 (PM),构成了重大的公共卫生挑战.
- 区分PM和简单高近视 (SHM) 对于预后和管理至关重要.
- 像轴长 (AL) 和折射误差 (RE) 这样的传统指标在区分这些条件方面存在局限性.
研究的目的:
- 在各种近视严重程度的眼睛后部曲的特征.
- 评估后眼曲度参数的诊断性能,以区分PM与SHM.
主要方法:
- 这是一项以人口为基础,对790名来自北京眼睛研究的参与者进行的横截面研究.
- 用光谱域光学连贯性断层扫描 (SD-OCT) 图像计算眼睛后部的曲率.
- 计算和分析了三个曲率参数 (曲率平均值,曲率最大值,曲率斑点).
主要成果:
- 眼睛后部曲率参数随近视的严重程度逐渐增加.
- 曲率参数表明,SHM和PM之间的急剧增加与其他近视群体相比.
- 曲率max在区分PM和SHM方面获得了最高的诊断性能 (AUROC 0.92),超过了AL和RE.
结论:
- 后眼曲是区分PM和SHM的一个有价值的生物标志物.
- 与传统指标相比,曲率参数显示出优越的诊断性能.
- 需要进一步的纵向研究来探索曲率对近视预后的预测价值.
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