白斑病变的预后因素和预后模型:系统性审查和元分析
Wei Lu1, Nannan Wang1, Xiaolin Fang2
1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, China.
Journal of dentistry
|March 19, 2025
概括
以前存在的白斑病变 (WSL) 和口腔卫生不良是正治疗期间发展新的WSL的关键风险因素. 综合性治疗前评估对于预防至关重要.
科学领域:
- 矯正牙科 矯正牙科是一種矯正牙科.
- 牙科公共卫生 牙科公共卫生
- 证据综合 证据综合
背景情况:
- 白斑病变 (WSLs) 是在正义牙科治疗期间的一个常见问题.
- 确定预后因素 (PF) 和模型 (PM) 可以帮助预防WSL.
研究的目的:
- 系统地审查现有证据,对PFs和PMs为WSLs在正牙患者.
- 评估确定PF和PM的证据的确定性.
主要方法:
- 在主要数据库 (PubMed,Embase等) 进行系统的文献搜索. 和灰色文学.
- 包括队列和病例控制研究;使用QUIPS和PROBAST进行偏差风险评估.
- 使用随机效应模型和GRADE评估证据确定性的预后估计的元分析.
主要成果:
- 32项研究确定了31个PF和一个PM.
- 治疗前的病变 (RR=3.87) 和口腔卫生 (RR=1.86) 是WSL发病率的显著 PF.
- 大多数PF和单一PM的证据确定性低至非常低.
结论:
- 治疗前的病变和口腔卫生是WSL发病率的重要预后因素.
- 目前的证据是有限的,强调了需要一个验证的预后模型.
- 综合性治疗前评估对于在正牙患者中预防WSL至关重要.
相关概念视频
Actuarial Approach
The actuarial approach, a statistical method originally developed for life insurance risk assessment, is widely used to calculate survival rates in clinical and population studies. This method accounts for participants lost to follow-up or those who die from causes unrelated to the study, ensuring a more accurate representation of survival probabilities.
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
Assumptions of Survival Analysis
Survival models analyze the time until one or more events occur, such as death in biological organisms or failure in mechanical systems. These models are widely used across fields like medicine, biology, engineering, and public health to study time-to-event phenomena. To ensure accurate results, survival analysis relies on key assumptions and careful study design.
Comparing the Survival Analysis of Two or More Groups
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and Cox...
Cancer Survival Analysis
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...


