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Updated: May 21, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

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Published on: October 26, 2015

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发现了具有ATP竞争力的PDHK1/2双抑制剂

Hongtao Xu1, Dong Ding1, Xingchun Han1

  • 1China Innovation Center of Roche, No. 371 Lishizhen Road, Shanghai, 201203, China.

Bioorganic & medicinal chemistry letters
|March 19, 2025
PubMed
概括

研究人员通过选和优化确定了新型的pyruvate脱酶激酶 (PDHKs) 抑制剂. 两种抑制剂系列显示出高强度和选择性,共价抑制剂改善细胞参与.

关键词:
协同抑制剂 协同抑制剂用于免疫代谢的激酶抑制剂.基于结构的设计设计.

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