[直接和间接方法的比较和应用,以确定凝血试验的参考间隔]
1Department of Clinical Laboratory, China-Japan Friendship Hospital, Beijing 100029, China.
概括
这项研究使用CN-6000分析仪确定了成年人凝血参数的参考间隔. 间接方法是健康个体的直接方法的可行的替代方案,但在患病的人群中需要谨慎.
科学领域:
- 临床化学 临床化学
- 血液学 血液学 血液学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 确定准确的参考间隔对于解释凝血试验结果至关重要.
- 自动凝血分析仪需要经过验证,局部化的参考间隔,以实现最佳的临床使用.
- 直接和间接方法为确定这些间隔提供了不同的方法.
研究的目的:
- 使用CN-6000分析仪确定成年人凝血参数 (APTT,PT,TT,Fib) 的参考间隔.
- 为了比较直接和间接方法在不同人群中确定这些间隔的适用性.
- 评估两种方法在健康,相对健康和患病的患者群体中的性能.
主要方法:
- 采用了横截面和回顾性研究设计.
- 直接方法涉及测试成年参与者 (18-64岁和≥65岁) 的凝血参数.
- 间接方法使用了refineR算法对非ICU患者的现有凝血数据.
主要成果:
- 使用CN-6000分析仪为APTT,PT,TT和Fib建立了局部参考间隔.
- 直接和间接方法在健康和相对健康的个体中产生了可比的结果.
- 在患有高疾病患病率的患者中,方法之间观察到显著差异,特别是在Fib.
结论:
- 成功建立了CN-6000分析仪的局部参考间隔.
- 间接方法是健康和相对健康的人群的直接方法的合适替代方法.
- 在患病率高的人群中,间接方法的实用性有限,需要仔细的临床解释.
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