维生素B12作为一种用于调节长期COVID相关视觉构造性缺陷的外周血液生物标志物的流行药物
Larissa M G Cassiano1,2, Jonas J de Paula3,4, Daniela V Rosa3,4
1Neurogenômica, Imunopatologia, Instituto René Rachou, Fiocruz, Av. Augusto de Lima, Belo Horizonte, 1517, Brazil.
Scientific reports
|March 20, 2025
概括
长期的COVID可能会导致与炎症相关的持续视觉构造缺陷 (VCD). 补充维生素B12可能有助于调节免疫标记物和表观遗传变化,为这种认知障碍提供潜在的治疗方法.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
背景情况:
- 轻微的COVID-19感染可能导致约25%的个体持续视觉构造缺陷 (VCD),与免疫标记物和脑成像改变有关.
- 维生素B12已经证明了通过表观遗传机制在COVID-19中调节高炎症的潜力.
研究的目的:
- 在长期COVID患者中调查与VCD相关的白细胞表达模式的生物标志物.
- 探索维生素B12在调节这些生物标志物和解决VCD方面的治疗潜力.
主要方法:
- 来自持久性VCD患者和对照组 (10-16个月后轻度COVID-19) 的全周围血液培养物被分析.
- 评估了11种生物标志物的白细胞表达,并探索了药理学维生素B12 (1nM) 对基因表达的影响.
- 研究了CCL11mRNA水平与促进体甲基化之间的相关性.
主要成果:
- 与对照组相比,持久性VCD患者显示CCL11和LIF的持续上调.
- 维生素B12在VCD患者的血液培养物中使CCL11mRNA水平正常化,神经保护性HGF上调,CSF2和CXCL10下调.
- 在CCL11mRNA与其促进物甲基化水平之间发现了反向相关性.
结论:
- 系统性炎症在与长期COVID相关的持续性VCD中发挥着重要作用.
- 维生素B12作为一种副药,作为治疗长期COVID相关认知障碍,特别是VCD的治疗策略具有前途.
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