相关实验视频

Updated: May 21, 2025

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
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Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

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对人类AGO蛋白的不同不结合状态进行比较的结构见解和功能分析

Panos Kakoulidis1,2, Eleni I Theotoki3,4, Vasiliki I Pantazopoulou5

  • 1Department of Informatics and Telecommunications, National and Kapodistrian University of Athens, 16122, Athens, Greece. pkakoulidis@di.uoa.gr.

Scientific reports
|March 20, 2025
PubMed
概括

人类阿尔戈诺特 (AGO) 蛋白质是基因调节的关键,表现出类似但却独特的结构动态. 我们的模拟揭示了独特的构造模式和与线粒分裂途径和离子的潜在相互作用.

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Conserved Binding Sites01:49

Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
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Conservation of Protein Domains Over Different Proteins

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Structural Protein Function

Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
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Ligand Binding and Linkage00:49

Ligand Binding and Linkage

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Gene Families01:57

Gene Families

Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
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An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
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