婴儿肠道中的原体被普遍诱导,并可能调节它们宿主的功能
Tamsin A Redgwell1, Jonathan Thorsen1,2, Marie-Agnès Petit3
1Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital, Herlev-Gentofte, Ledreborg Allé 34, DK-2820, Gentofte, Denmark.
NPJ biofilms and microbiomes
|March 20, 2025
概括
前体是婴儿肠道微生物组的关键组成部分,影响其功能. 大多数已识别的prophages都被诱导,无论环境因素如何,这表明了显著的宿主微生物相互作用.
科学领域:
- 微生物学 微生物学
- 病毒学 病毒学
- 人类肠道微生物组研究研究
背景情况:
- 肠道微生物组在健康和疾病中的作用已被证实.
- 肠道病毒组,特别是prophages,越来越多地被认为是重要的.
- 婴儿肠道中体诱导模式在很大程度上仍未研究.
研究的目的:
- 为了识别和描述婴儿肠道中假定的prophages.
- 调查这些菌体的功能性作用.
- 为了确定婴儿的prophage诱导模式.
主要方法:
- 来自1岁儿童的662个元基因组的分析.
- 识别了10645个假设的菌体 (病毒操作分类学单位).
- 对病毒和元基因组进行配对分析,以评估prophage诱导.
主要成果:
- 没有鉴定出核心普罗维龙;最常见的vOTU在70%的样本中被发现.
- 主导的prophage集群与Bacteroides菌体Hanky p00'有关,它携带产生多样性的反元素和囊多糖化合物合成基因.
- 发现婴儿肠道中的大多数瘤都是诱导的,不受环境干扰因素的影响.
结论:
- 前体是婴儿肠道微生物组的主要,动态的组成部分.
- 婴儿肠道菌体拥有功能性基因,可以影响微生物群.
- 吞体诱导是婴儿肠道中常见的现象,可能会影响宿主-微生物相互作用.
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