非洲血液性恶性瘤的流行:系统性审查和元分析
Zewudu Mulatie1, Dereje Mengesha Berta2, Alemu Gedefie3
1Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia. zewudumulatie@gmail.com.
Scientific reports
|March 20, 2025
概括
血液性恶性瘤,包括白血病和淋巴瘤,影响了非洲27.30%的人口. 儿童患病率高于成年人 (60.92%),这凸显了整个非洲大陆需要加强监测和诊断的必要性.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 血液性恶性瘤,血液和骨髓细胞的癌症是非洲疾病和死亡的重要原因.
- 非洲大陆缺乏关于这些不同瘤的流行情况的全面数据.
研究的目的:
- 系统地审查和分析非洲血性恶性瘤的综合流行情况.
- 根据国家,年龄,人口类型和研究设计来确定患病率的变化.
主要方法:
- 在2023年10月至11月期间,对六个电子数据库 (PubMed,谷歌学者,科学网,研究门,Embase,Scopus) 进行了系统的搜索.
- 来自34项涉及43099名参与者的合格研究的数据使用STATA-14.4中的随机效应模型进行了分析.
- 使用纽卡斯尔-太华尺度评估研究质量,使用I2统计数据评估异质性.
主要成果:
- 在非洲,血液性恶性瘤的综合流行率为27.30%,具有很高的异质性 (I2 = 99.2%).
- 白血病 (53.69%) 和淋巴瘤 (38.36%) 是最常见的类型.
- 亚组分析显示,肯尼亚的患病率最高 (44.69%),尼日利亚的患病率最低 (20.52%). 与成年人 (17.02%) 相比,儿童的患病率显著更高 (60.92%).
结论:
- 血液性恶性瘤在非洲是一个重大的公共卫生问题,总的流行率为27.30%.
- 这些发现强调了加强监测,早期检测和有针对性的干预措施的必要性,特别是对于儿科患者群体.
- 需要进一步的研究来探索区域差异和导致这些疾病高负担的特定风险因素.
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