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Updated: May 21, 2025

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通过修复基-CoA,CLYBL可以避免维生素B12的耗尽

Corey M Griffith1, Jean-François Conrotte1, Parisa Paydar1

  • 1Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.

Nature chemical biology
|March 20, 2025
PubMed
概括

酸酶β类蛋白 (CLYBL) 修复了酸循环的副产品malyl-CoA. 这一发现解释了CLYBL功能丧失的维生素B12缺乏症,因为malyl-CoA抑制了一个关键的B12依赖酶.

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