代谢健康的肥胖与抑郁症风险之间的关联:系统性审查和元分析
Jialin Deng1,2, Lu He3, Luokai Zhang1
1Department of Radiology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
International journal of obesity (2005)
|March 20, 2025
概括
代谢健康的肥胖 (MHO) 与更高的抑郁风险有关,特别是在女性和北美/欧洲人口中. 标准化MHO定义对于未来的研究和有针对性的干预至关重要.
科学领域:
- 代谢健康和精神病学
- 肥胖问题研究研究
- 流行病学 流行病学
背景情况:
- 代谢健康的肥胖症 (MHO) 描述的是肥胖但没有代谢异常的个体.
- MHO与心理健康之间的关系,特别是抑郁症风险,需要进一步研究.
- 现有研究存在不一致性,需要进行全面审查.
研究的目的:
- 系统地审查和综合有关代谢健康肥胖 (MHO) 和抑郁风险之间的相关证据.
- 为了在不同代谢健康和肥胖状况组中比较抑郁风险.
- 确定影响发现异质性的因素,如MHO定义和人口统计变量.
主要方法:
- 观察性研究 (队列和横截面) 的系统审查和元分析.
- 搜索的主要数据库 (EMBASE,PubMed,科学网,科克兰图书馆) 截至2024年6月.
- 使用随机效应模型,用子组分析和元回归来评估异质性.
主要成果:
- 患有MHO (OR1.08),代谢不健康的非肥胖 (OR1.15) 和代谢不健康的肥胖 (OR1.30) 个体与代谢健康的非肥胖相比,患抑郁症的风险增加.
- 这种关联在女性 (OR 1.14) 和来自北美 (OR 1.26) 和欧洲 (OR 1.23) 的人口中更为强烈.
- 异质性受到MHO定义和BMI截止值在研究中的变化的显著影响.
结论:
- MHO与抑郁症的风险增加有关,特别是在特定的人口和地理群体中.
- 建议针对高风险人群进行个性化干预,包括北美和欧洲的妇女和个人.
- 对MHO定义的标准化对于未来的研究至关重要,需要对不同人群进行前性研究.
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