在产前暴露于寨卡病毒后,学龄儿童的神经发育
Sarah B Mulkey1,2,3, Regan Andringa-Seed4, Elizabeth Corn4
1Zickler Family Prenatal Pediatrics Institute, Children's National Hospital, Washington, DC, USA. sbmulkey@childrensnational.org.
Pediatric research
|March 20, 2025
概括
与未暴露的同龄人相比,患有产前寨卡病毒 (ZIKV) 暴露的儿童的智商得分较低,特别是在视觉推理方面. 这突显了ZIKV暴露在幼儿时期对神经发育的潜在长期影响.
科学领域:
- 儿科神经发育 儿童神经发育
- 传染病流行病学 传染病流行病学
- 遗传性寨卡综合征是一种先天性寨卡综合征.
背景情况:
- 对于在学龄儿童与产前感染寨卡病毒 (ZIKV) 的神经发育结果的有限理解.
- 2015-2016年的ZIKV流行病影响了现在进入学龄的儿童.
研究的目的:
- 评估和比较暴露于ZIKV的哥伦比亚儿童在5-6岁时的神经发育与未暴露的对照.
- 为了确定ZIKV暴露儿童的特定认知和适应功能差异.
主要方法:
- 在哥伦比亚亚特兰蒂科进行的纵向队列研究,涉及48名暴露于ZIKV的儿童 (病例) 和118名年龄相匹配的对照.
- 在5-6岁时使用标准化措施评估多领域神经发育.
- 使用回归模型进行统计分析,并使用本杰明尼-霍赫伯格FDR对显著性进行校正.
主要成果:
- 与两组对照组相比,暴露于ZIKV的儿童 (病例) 的全尺度智商得分明显较低 (p=0.002).
- 视觉推理缺陷是ZIKV暴露儿童IQ分数较低的主要驱动因素 (p<0.001).
- 经历COVID-19相关学校延误的对照表现出更多的执行控制和适应性功能问题,而不是病例和按时控制.
结论:
- 产前ZIKV暴露与学龄儿童的认知能力下降,特别是智商降低有关.
- 暴露于ZIKV的儿童的神经发育差异可能会产生长期影响.
- 持续的随访对于了解产前ZIKV暴露对更高阶认知功能的长期影响至关重要.
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