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在癌症治疗中,VDAC2损失引起瘤破坏和炎症

Sujing Yuan1, Renqiang Sun1, Hao Shi1

  • 1Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.

Nature
|March 20, 2025
PubMed
概括

瘤细胞通过涉及电压依赖的离子通道2 (VDAC2) 的机制逃避免疫攻击. 通过使干扰素 (IFNγ) 触发细胞死亡和先天免疫反应,向VDAC2可增强抗瘤免疫力和免疫疗法的有效性.

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