在中国双胞胎怀孕中,孕期体重变化轨迹和围产期结果之间的关联
Mengmeng Li1,2, Wubulitalifu Dawuti2, Tianchen Wu3
1Institute of Reproductive and Child Health, Key Laboratory of Reproductive Health, Peking University, National Health Commission of the People's Republic of China, Beijing, 100191, China.
BMC pregnancy and childbirth
|March 20, 2025
概括
双胞胎怀孕中妊娠期体重增加模式显著影响围产期结果. 高体重增加降低了低出生体重和妊娠年龄的小风险,但对妊娠年龄的风险增加了很大,而低体重增加增加了早产和低出生体重的风险.
科学领域:
- 产科和妇科 产科和妇科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 围产期流行病学 围产期流行病学
背景情况:
- 妊娠期体重增加 (GWG) 是双胞胎怀孕的一个关键因素,影响母亲和婴儿的健康.
- 了解不同的GWG轨迹对于优化多胎妊娠中围产期结果至关重要.
研究的目的:
- 为了确定双胞胎怀孕中明显的妊娠体重增加 (GWG) 模式.
- 检查确定GWG轨迹与不良周产期结果之间的关联.
主要方法:
- 利用来自中美神经管缺陷预防合作项目的3393例双胞胎怀孕的数据.
- 使用隐性类增长建模 (LCGM) 来识别GWG模式.
- 应用多变量逻辑回归和通用估计方程 (GEE) 来分析与早产,低出生体重 (LBW),怀孕年龄小 (SGA) 和怀孕年龄大 (LGA) 的关联.
主要成果:
- 确定了三个GWG轨迹组:低增长 (32.36%),中等增长 (56.26%) 和高增长 (11.38%).
- 高增量组与中等增量组相比,LBW和SGA风险降低,但LGA风险增加.
- 低增长组表现出更高的早产,LBW和SGA的风险.
结论:
- 双胞胎怀孕中明显的妊娠体重增加模式与不良周产期结果的不同风险有关.
- 对GWG的监测和量身定制的管理对于改善双胞胎怀孕中产周健康至关重要.
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