药品对水生动物行为影响的证据 (EIPAAB):一个系统地图和开放访问数据库
Jake M Martin1,2,3,4, Marcus Michelangeli5,6,7, Michael G Bertram5,6,8
1Department of Wildlife, Fish and Environmental Studies, Swedish University of Agricultural Sciences, Umeå, Sweden. jake.martin@deakin.edu.au.
Environmental evidence
|March 20, 2025
概括
制药污染影响水生动物的行为,在过去15年中,研究的激增. 一个新的数据库整合了这些数据,突出了知识差距和风险评估的方法改进.
科学领域:
- 环境毒理学环境毒理学
- 水生生态毒理学 水生生态毒理学
- 行为生态学 行为生态学
背景情况:
- 制药污染在水生生态系统中越来越令人担忧.
- 行为终点对于化学品风险评估和监管活动越来越重要.
- 对药物对水生动物行为影响的研究的快速增长需要系统的合成.
研究的目的:
- 系统地识别,目录和综合对药物对水生动物行为影响的初级研究.
- 为科学家,政策制定者和环境管理者创建一个全面的开放访问数据库 (EIPAAB).
主要方法:
- 通过Web of Science和Scopus系统的文献搜索,并补充了其他来源.
- 用于搜索字符串开发的人口-暴露-比较-结果框架.
- 使用先验决策树进行两阶段选 (标题/摘要,全文);数据合成侧重于物种,化合物,行为和质量.
主要成果:
- 包括901个物品,代表了173个物种中的1739个物种对化合物的组合.
- 大多数研究集中在淡水环境中的光鱼,抗抑郁药是研究的最常见的制药组.
- 运动和大胆/焦虑行为是最被评估的; 报告和方法的不良做法通常被检测到.
结论:
- 在过去的15年里,对药物对水生动物行为影响的研究显著增加.
- 确定了定量综合和证据缺口的领域,以及报告和方法上的陷.
- EIPAAB数据库可以解决知识和方法差距,提高可复制性和风险评估中的使用.
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