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在患有败血症的儿童中,氧化应激和抗氧化剂状况
Hatice Feray Arı1, Murat Arı2, Serdal Ogut3
1Department of Pediatrics, Division of Pediatric Intensive Care Unit, Faculty of Medicine, Aydin Adnan Menderes University, Aydin, 09100, Turkey. dr.hferayyavas@gmail.com.
BMC pharmacology & toxicology
|March 20, 2025
概括
儿科败血症与氧化剂增加和抗氧化剂减少有关. 硫酸硫醇的水平可能有助于诊断重症儿童的败血症,有助于早期治疗和降低死亡率.
科学领域:
- 生物化学 生物化学
- 儿科重症监护 儿科重症监护
- 氧化压力研究研究 氧化压力研究
背景情况:
- 败血症在儿童中构成严重的危及生命的风险,需要早期识别和治疗以减少死亡率.
- 败血症的发病包括氧化和抗氧化剂标记物的不平衡,观察到氧化剂增加和抗氧化剂减少.
- 研究新型生物标志物,如二硫化物,对于改善儿科重症监护室 (PICU) 中的败血症诊断和管理至关重要.
研究的目的:
- 在儿科重症监护病房 (PICU) 检查和比较患有败血症和没有败血症的儿童的硫酸二醇水平.
- 评估二硫化物参数作为儿科败血症诊断工具的潜力.
主要方法:
- 一项队列研究涉及64名患有败血症的儿童和62名对照儿童,于2022年10月至2023年3月在PICU中进行.
- 采集,处理和储存血液样本,并使用ELISA套件方法分析二硫化物值.
- 测量的关键参数包括总氧化剂状态,8-OHdG,原生醇和醇/二硫化物比率.
主要成果:
- 与对照组相比,患有败血症的儿童的总氧化剂状况,血8-OHdG,总原生醇和原生/总醇百分比显著增加 (p <0.05).
- 相反,抗氧化剂参数,如总抗氧化剂状况,氧酶1活性,二硫化物和二硫化物/醇比率在败血症组明显较低 (p < 0.05).
结论:
- 该研究证实,患有败血症的重症儿童具有显著更高的氧化剂参数和较低的抗氧化剂参数.
- 二硫化物水平表明,它有可能作为重症儿童败血症的诊断生物标志物,补充现有的炎症标志物.
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