在有机暴露和晚年认知功能之间的关联中,种族和性别差异
Marianne Chanti-Ketterl1, María P Aranda2, Brenda L Plassman3
1Division of Behavioral Medicine & Neurosciences, Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University, Durham, North Carolina, USA.
概括
有机化农药与老年人的认知差异有关,因种族/种族和性别而异. 需要进一步的研究来了解它们在认知健康差异中的作用.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
背景情况:
- 有机化农药 (OCP) 是一种持久性环境污染物,在老年人群中具有未知的长期认知影响.
- 基于种族/种族和性别,OCP暴露可能会对认知功能产生不同的影响,从而导致健康差异.
研究的目的:
- 研究甲基农药水平与老年人认知功能之间的关联.
- 检查这些关联是否因种族/种族和性别而有所不同.
主要方法:
- 从NHANES (2011-2014) 对979名成年人 (60岁以上) 的认知功能和7种脂质调整的有机的分析.
- 认知功能通过包括记忆,口语流和数字替代在内的复合得分来评估.
- 权重概括估计方程用于建模关联,控制共变量;灵敏度分析包括BMI,收入与贫困比率和职业.
主要成果:
- 在种族和性别群体之间观察到认知结果和有机水平的显著差异.
- 认知表现和OCP暴露的变化表明OCP在认知差异中的潜在作用.
- 在调整了BMI,收入与贫困比例和职业之后,大多数特定的有机化合物相关性仍然显著.
结论:
- 研究结果强调了分析有机分布和认知功能的重要性,这些功能按种族和性别分层.
- 了解这些相互作用对于解决老年人认知健康差异至关重要.
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