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Updated: May 21, 2025

Protein Misfolding Cyclic Amplification of Prions
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Protein Misfolding Cyclic Amplification of Prions

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实验性动物模型的进化对子疾病的演变

Joseph P DeFranco1, Glenn C Telling1

  • 1Department of Microbiology, Immunology, and Pathology, Prion Research Center, Colorado State University, Fort Collins, Colorado, USA.

Journal of neurochemistry
|March 20, 2025
PubMed
概括

子疾病涉及致命的神经退行,由错误折叠的蛋白质 (PrPSc) 引起. 研究越来越多地使用动物模型,特别是动物,以了解子菌株的多样性并开发疗法.

关键词:
基因向的小鼠.普里昂病是什么?普里昂病是什么?子是一种子.菌株 菌株 菌株转基因小鼠 转基因小鼠

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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