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Updated: May 21, 2025

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由CYP-cl3催化的DHEA的两步有序选择性氧化修改策略

Qingbo Deng1, Peng He2, Zhen-Ming Lu1

  • 1School of Biotechnology, Jiangnan University, Wuxi 214122, P.R. China.

Journal of agricultural and food chemistry
|March 20, 2025
PubMed
概括

研究人员设计了一个P450二基酶,以高效地合成类固醇. 一个四重突变实现了99.9%的7α,15α-diOH-DHEA产量,改善了类固醇药物前体的生产.

关键词:
7α,15α-二H-DHEA 的使用.在CYP-cl3中.酶修改酶的改变类固醇氧化.

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