对T-cadherin在COVID-19病变发生,内皮功能障碍和肺纤维化中的新证据
Ekaterina Semina1, Vladimir Popov1, Nikita Khabibullin1
1Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia.
Frontiers in cell and developmental biology
|March 20, 2025
概括
缺乏T-cadherin可以防止肺纤维化和内皮功能障碍. 这项研究揭示了T-cadherin.
科学领域:
- 心血管生物学 心血管生物学
- 肺部医学 肺部医学
- 分子生物学分子生物学
背景情况:
- 由于COVID-19造成的多器官损伤的机制尚不清楚.
- 后急性继发症和内皮功能障碍是令人担忧的重大问题.
- 在COVID-19病变发生过程中T-cadherin的作用尚未被探索.
研究的目的:
- 调查T-cadherin在COVID-19病变发生过程中的作用.
- 检查T-cadherin在肺纤维化中的影响.
- 评估T-cadherin对内皮功能障碍的影响.
主要方法:
- 在死后的COVID-19肺样本中分析了T-cadherin表达.
- 利用培养的人体内皮细胞 (Ea.hy926) 来研究T-cadherin/VE-cadherin相互作用.
- 在白血素诱导的肺纤维化模型中使用T-cadherin淘汰 (Cdh13-/-) 小鼠.
- 在T-cadherin淘汰赛小鼠中研究了使用血管新素II的内皮功能障碍.
主要成果:
- 在COVID-19肺部观察到T-cadherin表达的减少,与VE-cadherin增加和β-catenin减少相关.
- 过度表达T-cadherin在内皮细胞中减少了VE-cadherinmRNA,这表明相互作用.
- 在小鼠中,T-cadherin 缺乏对白血素诱导的肺纤维化有保护作用.
- 在内皮功能障碍模型中缺少T-cadherin减少反应性氧物种和Nox2表达.
结论:
- 在COVID-19相关的肺损伤和内皮功能障碍中,T-cadherin起着重要作用.
- 缺乏T-cadherin显示出对肺纤维化有保护作用.
- 研究结果表明T-cadherin是COVID-19并发症的潜在治疗点.
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