对强迫症的深度大脑刺激导致伴随性易怒肠综合征的症状变化
Mohamed A Abdelnaim1,2, Tobias Hebel1, Verena Lang-Hambauer2,3
1Department of Psychiatry and Psychotherapy, University Regensburg, Regensburg, Germany.
Frontiers in psychiatry
|March 20, 2025
概括
床核终端 (BNST) 的深度大脑刺激 (DBS) 在患有强迫症 (OCD) 的患者中显示出缓解易怒肠综合征 (IBS) 症状的潜力. 需要进一步的研究来证实这些发现.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 精神病学是一个精神病学.
背景情况:
- 刺激性肠综合征 (IBS) 影响全球11%,与大脑-肠轴调节失调有关.
- IBS经常与诸如强迫症 (OCD) 等精神疾病同时发生.
- 深度大脑刺激 (DBS) 是一种治疗耐强迫症的治疗方法,有可能导致并发性IBS.
研究的目的:
- 为了研究DBS在床核末端 (BNST) 对治疗不耐药的强迫症患者的IBS症状的影响.
主要方法:
- 九名患有治疗阻断性强迫症的患者接受了针对BNST的DBS.
- 刺激性肠综合征 (GSRS-IBS) 的胃肠症状评分表和耶鲁-布朗强迫性强迫性表 (Y-BOCS) 用于评估.
- 患者在DBS前和12个月后的随访中进行了评估.
主要成果:
- 在基线临床相关的IBS患者中,三名患者在DBS后显示GSRS-IBS得分降低 (12-40%).
- 在剩余的6名患者中,有5名患者也表现出IBS症状的减少.
- 观察到整体IBS症状减少的趋势,以及强迫症症状的显著改善 (Y-BOCS从31.11降至16.50).
结论:
- BNST的DBS可能会减轻伴随性强迫症患者的IBS症状.
- 需要对更大的队列进行进一步的研究,以确定IBS症状的减少是否与强迫症的改善或DBS的独立作用有关.
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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
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