一项横截面研究评估了登革热患者的临床特征
Shubhransu Patro1, Arushi Choudhary1, Soumayan Mondal1
1General Medicine, Kalinga Institute of Medical Sciences, Bhubaneswar, IND.
Cureus
|March 20, 2025
概括
成年人严重的登革热感染与血小板数量低,肝酶升高,以及更频繁的器官干扰,如膜溢出和炎有关. 发烧是最常见的症状,但临床因素与住院时间没有很强的相关性.
科学领域:
- 传染性疾病 传染性疾病
- 临床医学 临床医学
- 公共卫生 公共卫生
背景情况:
- 登革热在热带和亚热带地区是一个重大的公共卫生问题.
- 虽然已知临床表现,但登革热特征与器官参与之间的相关性需要进一步调查.
研究的目的:
- 评估成年登革热患者的临床参数.
- 为了确定症状的同时出现和相关的临床参数.
主要方法:
- 在印度布巴内斯瓦尔KIMS的121名成年登革热患者 (NS1检测结果呈阳性) 的横截面研究.
- 患者被分为严重的登革热,有警告症状的登革热和没有警告症状的登革热.
- 分析了临床 (血液学,肝脏,脏) 和超声波检测结果 (多发性输液,,胆囊加厚,肝缩).
主要成果:
- 严重的登革热发生在24.0%的患者中;34.7%的患者有警告迹象.
- 严重的登革热患者的血小板数量中位数显著降低 (25.0 x 10^9/L),肝酶水平较高.
- 在严重的登革热病例中,增加了胆囊加厚,腹溢液与炎以及肝炎扩张的发病率.
- 发烧是最常见的症状,经常与吐 (33.9%) 和头痛 (32.2%) 一起发生.
- 在和皮肤皮疹,血清肌和尿素,以及细胞体积和血红蛋白之间发现了显著的相关性.
结论:
- 严重的登革热感染与血小板缺血,肝酶升高和器官参与度增加有关.
- 发烧是登革热患者的主要症状.
- 在临床参数和住院时间之间没有发现强烈的相关性.
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