埃坦布托尔诱导的视神经病变:发生率和危险因素的回顾性研究
Priti Singh1, Samendra Karkhur1, Vidhya Verma1
1Ophthalmology, All India Institute of Medical Sciences, Bhopal, Bhopal, IND.
Cureus
|March 20, 2025
概括
乙墨醇诱导的视神经病变 (EON) 发生在0.28%的结核病患者中. 较长的乙醇治疗持续时间和剂量增加了视力受损的风险,表明没有乙醇剂量是完全安全的.
科学领域:
- 眼科医生 眼科 眼科
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 乙醇是结核病治疗中的关键药物.
- 乙墨托尔诱导的视神经病变 (EON) 是已知的不良影响.
- 了解EON发生率和风险因素对于患者安全至关重要.
研究的目的:
- 为了确定中印度的三级护理中心中乙醇诱导的视神经病变 (EON) 的发生率.
- 为了确定与EON发展相关的风险因素.
主要方法:
- 在直接观察治疗短期 (DOTS) 中心进行了一项回顾性观察性研究.
- 收集了有关人口统计,并发病,结核病治疗细节和眼部症状的数据.
- 进行了回归分析,以确定与EON的关联.
主要成果:
- 在1676名患者中,EON的发病率为0.28% (13名).
- 较长的乙胺醇治疗持续时间与视网膜神经纤维层 (RNFL) 厚度的增加相关.
- 周周毛囊RNFL厚度的增加与乙胺醇片的总计数有关.
结论:
- 乙醇的毒性取决于剂量和持续时间.
- 长期治疗会增加视力损伤的风险.
- 即使在较低剂量的乙胺醇中也发现了不良反应,这表明没有剂量是完全安全的.
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