自然产品调节MAPK用于CRC治疗:一个有前途的战略
Lin Zhou1, Jinlong Zhang1, Kangning Zhao1
1The First Clinical Medical College, Shandong University of traditional Chinese medicine, Jinan, China.
Frontiers in pharmacology
|March 20, 2025
概括
自然产品可能通过向MAPK通路提供新的结直肠癌 (CRC) 治疗方法. 本综述探讨了47项关于自然化合物的研究及其对CRC中MAPK信号传递的影响.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 结肠直肠癌 (CRC) 是一种普遍存在的消化系统恶性病变,其致病性尚未完全理解,涉及遗传学,免疫,炎症和异常信号通路.
- 中原激活蛋白激酶 (MAPK) 途径,Ser/Thr激酶家族,对于细胞过程至关重要,包括增殖,分化,亡,血管新生和转移.
- MAPK通路的激活越来越多地与CRC风险有关,这表明它是一个潜在的治疗点.
研究的目的:
- 审查最近 (2010-2024) 针对针对结直肠癌中MAPK通路的天然产品的研究.
- 根据MAPK信号传递的自然产品调制来确定CRC的潜在治疗策略.
- 为开发来自自然来源的新型CRC药物提供基础.
主要方法:
- 使用PubMed,Web of Science和CNKI数据库进行了系统的文献搜索.
- 关键词包括"结肠直肠癌"",天然产品"",MAPK通路"",ERK"",P38"和"JNK".
- 包括2010年至2024年间发表的研究,导致检索47篇相关文章.
主要成果:
- 有证据表明,MAPK通路激活和CRC发展之间存在强烈的相关性.
- 自然产品在调节MAPK相关蛋白质方面显示出显著的潜力.
- 在CRC的背景下,特定的天然化合物可能会影响关键的MAPK信号组件,如ERK,P38和JNK.
结论:
- 用天然产品准MAPK通路为结直肠癌提供了一个有前途的治疗途径.
- 对天然产品衍生的MAPK抑制剂的进一步研究可能会导致创新的CRC治疗方法.
- 本次审查巩固了当前的知识,促进了CRC患者未来的药物开发.
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