单次高剂量维生素D给重症维生素D缺乏儿科患者的效果:一项随机试验
Mrityunjay Sakkarwal1, Pallavi Pallavi1, Urmila Jhamb1
1Department of Pediatrics, Maulana Azad Medical College, New Delhi, India.
概括
一次高剂量的维生素D有效地增加了严重病症儿童的维生素D水平. 然而,这种干预措施并没有显著改善维生素D缺乏症儿科患者的死亡率或其他临床结果.
科学领域:
- 儿科重症监护医学 儿科重症监护医学
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 维生素D缺乏是严重疾病的常见,可修改的危险因素.
- 它对重症和危急儿童的结果的影响需要进一步调查.
研究的目的:
- 为了评估单次高剂量维生素D补充剂对重症,维生素D缺乏儿童死亡率的影响.
- 为了评估干预后维生素D水平的变化.
主要方法:
- 一项随机对照试验,涉及250名维生素D缺乏症儿童 (1个月-12岁) 在儿科重症监护室 (PICU).
- 组A通过肌肉注射获得了10,000U/kg胆醇;组B没有接受任何干预.
- 血清维生素D,,酸盐和副甲状腺激素水平被监测.
主要成果:
- 在死亡率 (p=0.439),PICU停留 (p=0.57) 或机械通风需求 (p=0.449) 中,两组之间没有统计学上显著的差异.
- 干预组在72小时后观察到维生素D水平显著增加 (p=0).
- 对严重与不那么严重的缺陷的子组分析显示了类似的结果.
结论:
- 单次高剂量维生素D的使用成功地提高了重症儿童的维生素D水平.
- 这种干预措施没有令人信服地改善PICU中维生素D缺乏的儿科患者的临床结果或死亡率.
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