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身体活动对慢性广泛疼痛的影响:从元分析和双样本孟德尔随机化中的见解

Chongjie Yao^1,2,3, Yuchen Zhang^2,3, Sizheng Steven Zhao⁴

¹Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, People's Republic of China.

Journal of pain research

|March 20, 2025

概括

身体活动 (PA) 有效地治疗慢性广泛疼痛 (CWP) 和纤维肌痛症状. 高强度运动和三个月的持续时间显示了对疼痛,抑郁和生活质量最显著的益处.

科学领域:

类风湿病学类风湿病学
运动医学运动医学
遗传学遗传学是一种遗传学.

背景情况:

慢性广泛疼痛 (CWP) 是影响健康的关键纤维肌痛症状.
建议进行体力活动 (PA),但缺乏标准化处方.
本研究研究了PA在CWP预防和治疗中的作用,考虑了模式,持续时间和强度.

研究的目的:

研究身体活动 (PA) 对慢性普遍疼痛 (CWP) 的影响.
分析PA模式,治疗持续时间和强度如何影响CWP结果.
结合临床和遗传证据,全面了解PA在CWP管理中的有效性.

主要方法:

对10个数据库 (2014年1月至2024年7月) 进行系统审查,包括针对CWP/纤维肌痛的PA的随机对照试验.
用固定或随机效应模型对11项研究 (540名参与者) 的元分析.
门德尔随机化 (MR) 分析,以评估PA强度和CWP风险之间的遗传联系.

主要成果:

通过PA干预可显著改善疼痛感知 (MD:-1.47),抑郁 (MD:-4.77),以及生活质量 (SMD:-1.43).
MR 分析表明,各种 PA 强度,包括步行,DIY 活动和劳累性体育运动,与 CWP 易感性降低有关.
特定的PA强度,如快乐步行 (OR:0.950) 和艰苦的运动 (OR:0.923) 显示出保护作用.

结论:

对于CWP患者来说,PA干预有益,改善疼痛,情绪和生活质量.
建议治疗时间大约为三个月,Ba-Duan-Jin显示出潜在的有效性.
高强度的PA显示出对CWP的最显著的保护作用.

关键词:

慢性广泛的疼痛慢性广泛的疼痛运动就是炼身体.纤维肌痛是一种纤维肌痛.身体活动身体活动

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